Doxylamine is a first-generation antihistamine with strong sedative properties. It belongs to the ethanolamine class of antihistamines and works by blocking histamine H1 receptors in the body. This action helps reduce allergy symptoms such as runny nose, sneezing, and itchy or watery eyes. Due to its sedative effect, doxylamine is commonly used as a short-term treatment for insomnia. It is also included in combination therapies to manage nausea and vomiting during pregnancy. The drug was first developed in the mid-20th century and has been widely used since then. Doxylamine is available in both tablet and liquid forms. It is generally considered safe when used at recommended doses. Its dual action as an antihistamine and sedative makes it versatile in clinical use. Doxylamine remains an important medication in allergy and sleep disorder management.
