Diosmin is a naturally occurring flavonoid primarily found in citrus fruits and widely used for its vascular-protective properties. It belongs to the class of bioflavonoids called flavone glycosides and exhibits antioxidant and anti-inflammatory effects. Diosmin is commonly used to improve venous tone, reduce capillary permeability, and support lymphatic drainage. It is particularly effective in managing chronic venous insufficiency, varicose veins, and hemorrhoidal conditions. The compound enhances microcirculation and helps alleviate symptoms such as swelling, heaviness, and pain in the legs. Diosmin can be administered orally, often in combination with other flavonoids like hesperidin, to increase therapeutic efficacy. It was first extracted and studied in the 20th century for its vascular benefits. Its mechanism involves strengthening blood vessel walls and reducing inflammation in the vascular endothelium. Diosmin is well-tolerated with minimal side effects, making it suitable for long-term use. Today, it remains a key agent in phlebotropic therapy and vascular health management.
