Dicycloverine, also known as dicyclomine, is an anticholinergic drug used to relieve gastrointestinal smooth muscle spasms, particularly in conditions like irritable bowel syndrome (IBS). It works by blocking muscarinic receptors, which reduces involuntary contractions of the gut, easing abdominal pain, cramping, and discomfort. The drug was first synthesized in the 1940s–50s during research into synthetic anticholinergic agents for gastrointestinal disorders and later gained approval for treating spastic colon and functional bowel problems. Over the years, it became a standard therapy for IBS because of its effectiveness in targeting gut smooth muscles with relatively fewer systemic side effects. Even though newer medications have emerged, dicycloverine continues to be a valuable option in managing gut motility disorders.
