Demoxepam is a benzodiazepine with anxiolytic, sedative, and muscle-relaxant effects, acting by enhancing GABA activity in the central nervous system to reduce neuronal excitability and induce calming effects. Developed in the mid-20th century as part of the benzodiazepine class, it was designed to provide effective anxiety relief with a potentially safer profile than older sedatives and barbiturates. Metabolized in the liver with an intermediate duration of action, demoxepam has been used for short- to medium-term management of anxiety and tension, reflecting the evolution of benzodiazepine therapy toward targeted CNS modulation with reduced side effects and toxicity.
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