Cyclopentolate is a synthetic anticholinergic drug primarily used in ophthalmology to dilate the pupil and temporarily paralyze accommodation. It was developed in the mid-20th century as part of efforts to create safer and faster-acting mydriatic agents. Before its introduction, drugs like atropine were widely used but had long durations of action. Cyclopentolate offered a shorter onset and recovery time, making it more suitable for routine eye examinations. Its chemical structure allows it to effectively block muscarinic receptors in the eye. The drug quickly gained acceptance in clinical practice due to its predictable effects. It became especially useful in pediatric and diagnostic ophthalmology. Over time, cyclopentolate was included in major pharmacopeias worldwide. Its stability and effectiveness led to standardized formulations such as cyclopentolate hydrochloride. Today, cyclopentolate remains an important diagnostic tool in eye care.
