Amorolfine is a broad-spectrum antifungal agent primarily used topically to treat superficial fungal infections, including onychomycosis (nail fungus) and skin dermatophytoses. It belongs to the morpholine class of antifungals and works by inhibiting fungal sterol biosynthesis, disrupting cell membrane integrity, and causing fungal cell death. Developed in the late 20th century, amorolfine offered an alternative to earlier antifungals with improved efficacy against both dermatophytes and yeasts and a favorable safety profile. Available in formulations such as nail lacquers and creams, it allows localized treatment with minimal systemic absorption, making it a mainstay in dermatology for managing chronic or resistant superficial fungal infections.
