Amodiaquine is a 4-aminoquinoline antimalarial drug developed in the mid-20th century as an alternative to chloroquine. It treats malaria caused by Plasmodium falciparum and Plasmodium vivax by disrupting the parasite’s hemoglobin digestion. First widely used in the 1970s–80s, especially in Africa, it became important in combination therapies like artesunate–amodiaquine to combat resistance. Its chemical structure, featuring a 4-aminoquinoline core with a hydroxylated side chain, gives it potent antimalarial activity and distinctive pharmacological properties.
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