Alimemazine, also known as trimeprazine, is a first-generation phenothiazine derivative with antihistaminic, sedative, and antiemetic properties, primarily used to manage allergic conditions, pruritus, and agitation or sleep disturbances. It works by blocking histamine H1 receptors and exerting central nervous system depressant effects, leading to sedation and relief of allergic symptoms. Developed in the mid-20th century as part of research into phenothiazine compounds, alimemazine was introduced to provide a safer alternative with potent antihistaminic activity and manageable side effects, eventually gaining widespread use in dermatology, pediatrics, and psychiatry for its sedative and anti-allergic benefits.
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