Iohexol is a non-ionic, low-osmolar iodinated contrast agent widely used in medical imaging. It enhances the visibility of blood vessels, organs, and tissues during diagnostic procedures like CT scans, angiography, and urography. The iodine in iohexol absorbs X-rays, providing high-quality images for accurate diagnosis. Its non-ionic nature reduces the risk of allergic and osmotic side effects compared to older ionic contrast agents. Iohexol is water-soluble, rapidly distributed in the extracellular fluid, and excreted unchanged by the kidneys. It does not undergo metabolism, making it predictable and safe for patients. The drug is suitable for adults and children, with dosage adjusted according to weight and procedure. Iohexol’s low toxicity and high efficacy make it a preferred contrast medium in modern radiology. Proper hydration before and after administration helps prevent renal complications. Overall, iohexol plays a critical role in enhancing diagnostic imaging and patient care.