N-dehydroxylated metabolite is a metabolite formed when an N-hydroxyl group (-N–OH) is removed from a parent compound during metabolism, usually through enzymatic reduction. This biotransformation, primarily occurring in the liver, can alter the compound’s pharmacological activity, toxicity, and elimination. N-dehydroxylation is an important metabolic pathway for several drugs and xenobiotics, producing metabolites that may be less active, inactive, or, in some cases, possess different biological or toxicological properties compared with the parent compound.