Sofosbuvir Ethyl Ester

Category

Sofosbuvir

CAS Number

1064684-30-5

Molecular Formula

C21H27FN3O9P

Molecular Weight

515.42

Catelogue Number

MLS-SOF-WS/01

Synonym

(2S)-Ethyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate|(2S)-ethyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate.|Ethyl sofosbuvir;|Sofosbuvir Ethyl Ester;

Keywords

Heterocycles

Impurities

Nucleotides

Bases & Related Reagents

Pharmaceuticals

Intermediates & Fine Chemicals

Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Sofosbuvir Ethyl Ester

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