Rifapentine

Rifapentine was first synthesized in 1965 by the same company that produced rifampicin. The drug was approved by the Food and Drug Administration (FDA) in June 1998. It is made from rifampicin.Rifapentine is a rifamycin antibiotic that is similar in structure and activity to rifampin and rifabutin and that is used in combination with other agents as therapy of tuberculosis, particularly in once or twice weekly regimens. Rifapentine is associated with transient and asymptomatic elevations in serum aminotransferase and is a likely cause of clinically apparent acute liver injury.