(S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Impurity in commercial preparations of Bortezomib
Bortezomib Impurity G
Bortezomib Impurity 48
Bortezomib Hydroxy Impurity (1S,2S)-Isomer
metabolites,impurities,pharmaceutical standards,intermediates,fine chemicals
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